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. 2015 Sep 14;10(9):e0137696. doi: 10.1371/journal.pone.0137696

Fig 4. Predicted motif containing genes global set enrichment analysis.

Fig 4

A) The list of motif-containing genes predicted by RPTS was analyzed by GSEA for pathway enrichment of known oncogenic pathways. Each individual block is a functional grouping of pathways, individual pathways are noted horizontally, gene names are noted vertically. B) GSEA individual pathway enrichment analysis. Each pathway had a p-value of less than 0.05, and an enrichment score of greater than 1.7-fold enrichment. When analyzed as a total group, many of these pathways are implicated in the progression of EMT, cancer, and metastasis. C) Previous data suggests the mutation of single bases in RBP consensus motifs causes a disruption of the complex formation. This panel shows the number of SNP records contained in dbSNP (Entrez) for each RPTS motif-containing prediction. There are significant numbers of SNP mutations that occur in the loci of these genes, it is statistically plausible that some of these mutations occur within the boundaries of individual RBP consensus motif.