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. 2015 Sep 14;10(9):e0135388. doi: 10.1371/journal.pone.0135388

Fig 2. Accelerated hematological recovery of peripheral blood in NHPs injected with entolimod 16–48 hours post-irradiation.

Fig 2

NHPs were treated with a single injection of entolimod at 16–48 hours after LD50/40 or LD75/40 TBI. A, C, E, G: Effect of 40 μg/kg entolimod administered at different time points (16, 25 or 48 hours) after 6.5 Gy TBI (LD75/40; study Rs-06; N = 8–12). B, D, F, H: Effect of different entolimod doses (10 or 40 μg/kg) administered at 25 hours after 6.75 Gy TBI (LD75/40; study Rs-14; N = 10). Cytopenia/anemia thresholds: dotted lines—Grade 3 (platelets <50,000/μL; neutrophils <1,000/μL; hemoglobin <80 g/L); dashed lines—Grade 4 (platelets <10,000/μL; neutrophils <500/μL; hemoglobin <65 g/L). Error bars represent standard errors.