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. 2015 Sep 2;6:8084. doi: 10.1038/ncomms9084

Figure 6. miRNAs contribute to the regulation of glucose-induced insulin secretion and β-cell proliferation.

Figure 6

Dissociated P10 (a–j) or adult (k–n) rat islet cells were transfected with the indicated anti-miRs (a–d,f–l,n) or miRNA mimics (e,j,k,m). Two days later, insulin release and content was assessed in P10 (a–e) or adult (k,l) islet cells incubated at 2 or 20 mM glucose (n=5–7). The proliferating insulin+ cells from P10 (f,g,h,i,j) or adult (m,n) rats was assessed by Ki67 staining (n=6–7). All data are means±s.d. Statistical significance versus anti-ctrl or Ctrl was assessed by ANOVA: *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.