Table 1.

Possible mammalian UBE3A substrates.

Substrates/Interactors	Disease	Citation
ANXA1	ASD	Shimoji et al., 2009; Correia et al., 2014
AR	ASD	Khan et al., 2006; Henningsson et al., 2009
Arc	AS, Fragile X	Park et al., 2008; Greer et al., 2010; Mandel-Brehm et al., 2015
CDKN1B	ASD	Mishra et al., 2009; Grey et al., 2013
DLG1	ASD	Matsumoto et al., 2006; Li et al., 2014
Ephexin5	Epilepsy	Margolis et al., 2010; Veeramah et al., 2013
ESR2	Asperger syndrome, ASD	Picard et al., 2008; Chakrabarti et al., 2009
Herc2	AS, ASD	Kühnle et al., 2011; Puffenberger et al., 2012; Harlalka et al., 2013
mGluR5	AS, Fragile X	Dölen et al., 2007; Pignatelli et al., 2014
SOD1	ASD	Mishra et al., 2013; Kovac et al., 2014
TSC1	AS, TS, ASD	Smalley, 1998; Sun et al., 2015
TSC2	AS, TS, ASD	Smalley, 1998; Zheng et al., 2008; Sun et al., 2015
UBE3A	AS, ASD	Schwarz et al., 1998; Nurmi et al., 2001

AS, Angelman Syndrome; TS, Tuberous sclerosis; ASD, Autism spectrum disorder.