Table 1.
Right heart hemodynamics at 4 weeks.
| Group (n) |
RNU_M (8) |
RNU_F (8) |
SU_M (8) |
SU_F (11) |
|---|---|---|---|---|
| Semaxanib (mg/kg) | 0 | 0 | 40 | 40 |
| Heart rate (beat/min) | 269 ± 37 | 311 ± 35 | 296 ± 48 | 280 ± 73 |
| RVESP (mm Hg) | 21 ± 2.5 | 24.3 ± 8.1 | 66.3 ± 8.9∗#§ | 29.5 ± 13.4 |
| RVEDP (mm Hg) | 1.5 ± 3.5 | 3 ± 3.6 | 6.2 ± 2.8§ | 2.1 ± 4.3 |
| CO (mL/min) | 134 ± 4 | 122 ± 5 | 58 ± 24∗#§ | 89 ± 17 |
| PVR (dyn·s·cm−5) | 0.013 ± 0.002 | 0.016 ± 0.006 | 0.103 ± 0.06∗#§ | 0.027 ± 0.01 |
| dP/dt max (mm Hg/s) | 1173 ± 161 | 1311 ± 414 | 2636 ± 495∗#§ | 1374 ± 320 |
| dP/dt min (mm Hg/s) | −1318 ± 37 | −871 ± 232 | −2370 ± 912∗#§ | −1072 ± 415 |
| E es (mm Hg/µL) | 0.19 ± 0.05 | 0.21 ± 0.15 | 0.12 ± 0.06∗#§ | 0.18 ± 0.05 |
| E a (mm Hg/µL) | 0.04 ± 0.01 | 0.06 ± 0.03 | 0.33 ± 0.12∗#§ | 0.09 ± 0.02 |
| E es/E a | 4.75 ± 0.63 | 3.5 ± 0.45 | 0.36 ± 0.17∗#§ | 2.1 ± 0.34 |
RVESP: right ventricular end-systolic pressure; RVEDP: right ventricular end-diastolic pressure; CO: cardiac output; PVR: pulmonary vascular resistance; dP/dt max: right ventricular maximal isovolumic rate of development of ventricular pressure; dP/dt min: right ventricular minimal isovolumic rate of development of ventricular pressure. Other abbreviations are in text. ∗ explains P < 0.05 for comparison with SU_F; # explains P < 0.05 for comparison with RNU_M; § explains P < 0.05 for comparison with RNU_F.