Table 1.

Natural products that can overcome drug resistance without mechanistic information.

Compound name	Dose	Cell model	Chemodrug	IDS1	Reference
Single compound
4′-Methylether-scutellarein	20 μg/mL	JAR/VP16	Etoposide	5.0	[61]
Dauricine	2.5 μg/mL	K562/ADM	Doxorubicin	5.0	[62]
Dihydroartemisinin	0.3 μM	A549/CDDP	Cisplatin	12.3	[63]
Ginsenoside Rh2	40 μM	MCF/ADM	Doxorubicin	31.1	[64]
Isorhynchophylline	1.5–3 μg/mL	A549/DDP	Various	7.2–24.3	[65–67]
Ligustrazine	2.6–10 μg/mL	K562/ADM	Doxorubicin	6.0–178	[68, 69]
Matrine	50 μg/mL	K562/ADM	Doxorubicin	2.2	[70]
Peiminine	20 μg/mL	SGC7901/VCR	Various	6–27	[71]
Schizandrol A	25 μM	HL60/ADR	Daunorubicin	8	[72]
Tanshinone II A	0.2 μg/mL	MCF/ADM	Doxorubicin	2.5	[73]
Single herb extract
Eleutherococcus senticosus	200 μg/mL	K562/ADR	Daunomycin	4.2	[74]
Andrographis paniculata	2.4 μg/mL	CHT8/5FU	Various	2.1–2.2	[75]
Indigowoad root	31 μg/mL	BEL7404/ADM	Doxorubicin	4.8	[76]
Formula extract
Danggui Buxue recipe	300 μg/mL	SGC7901/ADR	Doxorubicin	2.8	[77]
Fufang Jinzi recipe	5 μg/mL	K562/VCR	Vincristine	3.6	[78]

¹IDS, increase in drug sensitivity (x-fold).

IDS = IC50 in control group/IC50 in experimental group.