Table 5.
Natural products overcome drug resistance in serum pharmacology studies.
| Name | Dose (days) | Serum dose1 | Cell model | Chemodrug | IDS2 | Reference |
|---|---|---|---|---|---|---|
| Buzhong Yiqi Tang | 5.7 g/kg (3) | 15 | A549/DDP | Cisplatin | 3 | [161] |
| Jiedu Huayu recipe | 3 g/kg (3) | 10 | HL60/Adr | Doxorubicin | 8.4 | [162] |
| Scutellariae barbatae | 14.1 g/kg (4) | 0.5 | K562/A02 | Various | 2.2–5.4 | [163] |
| Shehuang Xiaoliu | 29.7 g/kg (10) | 20 | Bel7402 | Doxorubicin | 8.3 | [164] |
| Zedoary turmeric oil | 0.8 mg/kg (3) | 20 | SGC7901/CDDP | Verapamil | 6.1 | [165] |
1Percentage of serum being tested in addition to the conventional 10% of fetal bovine serum in cell culture.
2IDS, increase in drug sensitivity (x-fold).
IDS = IC50 in control group/IC50 in experimental group.