TABLE III. Inosine triphosphatase (ITPA) alleles frequencies in relation to demographics and haemoglobin (Hb) levels during treatment in hepatitis C virus (HCV) patients (n = 97).
| ITPA SNPs |
||||
|---|---|---|---|---|
| rs7270101 |
rs1127354 |
|||
| AA | AC/CC | CC | AC | |
| Anemiaa [n (%)] | ||||
| Yes | 70 (87.5) | 12 (70.6) | 81 (86.2) | 1 (33.3) |
| No | 10 (12.5) | 5 (29.4) | 13 (13.8) | 2 (66.7) |
| Genderb [n (%)] | ||||
| Male with anaemia | 21 (80.7) | 5 (19.3) | 26 (100) | 0 (0) |
| Female with anaemia | 49 (87.5) | 7 (12.5) | 55 (98.2) | 1 (1.8) |
| Hb at baseline (mean ± SD) | ||||
| Male | 14.4 ± 2.3 | 14.9 ± 1.0 | 14.5 ± 2.1 | 14.9 ± 0.9 |
| Female | 13.6 ± 1.0 | 13.5 ± 0,7 | 13.6 ± 0.9 | 12.9 ± 0.0 |
| Hb at week 4 (mean ± SD) | ||||
| Male | 12.8 ± 1.4 | 13.6 ± 0.9 | 12.6 ± 1.5 | 16.0 ± 0.0 |
| Female | 12.0 ± 1.6 | 12.5 ± 0.9 | 12.0 ± 1.5 | 13.0 ± 0.0 |
| Hb at week 8 (mean ± SD) | ||||
| Male | 11.4 ± 1.4 | 11.9 ± 1.0 | 11.3 ± 1.1 | 15.0 ± 0.7 |
| Female | 10.6 ± 1.2 | 10.8 ± 1.7 | 10.7 ± 1.2 | 9.0 ± 0.0 |
| Hb at week 12 (mean ± SD) | ||||
| Male | 10.9 ± 1.9 | 12.0 ± 1.6 | 10.9 ± 1.8 | 14.2 ± 0.9 |
| Female | 10.3 ± 1.1 | 10.5 ± 1.3 | 10.3 ± 1.0 | 7.0 ± 0.0 |
a: defined as Hb levels < 10 g/dL and/or decline > 2 g/dL; b: male = 37, female = 60; SD: standard deviation; SNP: single nucleotide polymorphisms.