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. 2015 Sep 15;6:199. doi: 10.3389/fphar.2015.00199

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Copyright © 2015 Nishimura, Sasagawa, Ariyoshi, Ichikawa, Shimada, Kawaguchi, Kawase, Yamamoto, Uehara, Yanai, Takata and Tanaka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of transcriptional regulators for genes with changed expression levels common to RSV and CR in DIO zebrafish. (A) Correlation of gene expression changes induced by RSV and CR in DIO zebrafish. (B) Venn diagram of the numbers of DEG by RSV and CR in DIO zebrafish. (C) A regulatory network identified by iRegulon for the nine genes common between the RSV and CR groups. Genes shown in blue and red are decreased and increased, respectively, by RSV or CR. (D) A regulatory network identified by Pathway Studio for seven regulators and their six target genes. Genes shown in blue and red indicate decreased and increased expression, respectively, by RSV or CR.