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. 2015 Sep 15;6:199. doi: 10.3389/fphar.2015.00199

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Copyright © 2015 Nishimura, Sasagawa, Ariyoshi, Ichikawa, Shimada, Kawaguchi, Kawase, Yamamoto, Uehara, Yanai, Takata and Tanaka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of the regulatory network for genes dysregulated in obese humans. (A) Correlation of genes dysregulated in adipose tissues from female and male obese humans. (B) Venn diagram of the numbers of DEG in obese females and males. (C) A regulatory network identified by iRegulon for the 46 common genes between obese females and males. Genes shown in blue and red indicate decreased and increased expression, respectively, by obesity. (D) A regulatory network identified by Pathway Studio for five regulators and their 18 target genes. Genes shown in blue and red indicate decreased and increased expression, respectively, by obesity.