Table 2. Antitumor Activity in the HCT116 Xenograft Model upon Treatment with Newly Synthesized Derivatives.

compd	dose (mg/kg)	T/C (%)a	mortality
4	150	23c	0/6
4	75	43b	0/6
4	25	62b	0/6
5a	75	9c	0/6
5a	25	21c	0/6
5b	25	26c	0/6
5c	25	19c	0/6
5d	25	11c	0/6
6a	25	12c	0/6
6a	10	31b	0/6

^aT/C (%) = (mean tumor weight of treated group)/(mean tumor weight of control group) × 100, n = 6.

^b*p < 0.0001.

^c**p < 0.00001 vs control.