. 2015 Aug 3;6(9):961–965. doi: 10.1021/ml500526p

Table 1. Key Amide Transformations^a.

graphic file with name ml-2014-00526p_0004.jpg

Cpd	R₁	B-RAF^V600E^b	pERK SKMEL-28^c	SKMEL-28^d
2	–CONHMe	0.045 (1)	0.28 (3)	0.90 (3)
3	–NHCOMe	0.003 (1)	0.044 (7)	0.18 (8)
4	2-imidazolyl	0.090 (1)	0.39 (1)

IC₅₀ in μM. Numbers in parentheses represent number of determinations.

B-RAF^V600E enzymatic assay.^6,7 Assay variability within 2-fold of the mean value of the control.

pERK SKMEL target modulation.^5,9 Assay variability within 3-fold of mean value for applicable entries.

SKMEL-28 cell proliferation assay.^5,9 Assay variability within 3-fold of mean value.

Table 1. Key Amide Transformationsa.