Table 2. Antiproliferation Activities for Compounds Arising from Modifications to the Left-Hand Side^a.

^aData represents an average of at least two separate determinations. Standard deviations are reported in the Supporting Information and vary by less than ±50%.

^bAthymic nude mice were implanted with matrigel plugs containing 5 × 10⁶ H1975 cells. Animals (n = 3) were treated with control or compound (30 mg/kg po dose). Plug and plasma samples were collected 4 h post sample administration. Results denotes % p-EGFR/PRAS40 vs control. NT = not tested.