Table 3. Cell Signaling: Inhibition of p-EGFR by MSDa.
compd | H1975 IC50 (nM) | HCC827 IC50 (nM) | A431 IC50 (nM) |
---|---|---|---|
AZD9291 | 15 | 6 | 348 |
1 | 3 | 3 | 50 |
14 | 4 | 12 | 386 |
23 | 6 | 12 | 521 |
24 | 4 | 9 | 1054 |
Data represent an average of at least two separate determinations. Standard deviations are reported in the Supporting Information and vary by less than ±50%.