Table 5. In Vivo Exposures of Selected Biphenyl Analogues.
Cmpda | 45 | 46 | 50 | 51 | 63 | 64 | 65 | 66 | 67 |
---|---|---|---|---|---|---|---|---|---|
[plasma] μM, 2 h | 9 | 19 | 0.6 | 5.6 | 0 | 0.2 | 0 | 0.4 | 2.5 |
[plasma] μM, 6 h | 3 | 2.4 | 0.1 | 1.9 | 0 | 0.01 | 0 | 0.03 | 0.1 |
20 mg/kg p.o.
Cmpda | 45 | 46 | 50 | 51 | 63 | 64 | 65 | 66 | 67 |
---|---|---|---|---|---|---|---|---|---|
[plasma] μM, 2 h | 9 | 19 | 0.6 | 5.6 | 0 | 0.2 | 0 | 0.4 | 2.5 |
[plasma] μM, 6 h | 3 | 2.4 | 0.1 | 1.9 | 0 | 0.01 | 0 | 0.03 | 0.1 |
20 mg/kg p.o.