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. 2015 Aug 6;6(9):993–997. doi: 10.1021/acsmedchemlett.5b00208

Figure 2.

Figure 2

(A) Compounds 41 and 43 effectively inhibited the tubulin polymerization in vitro. The microtubule polymerization was monitored by measuring the absorbance at 340 nm in the absence or presence of drugs (N = 3). A representative experiment is shown. Vehicle control (sky blue); paclitaxel (5 μM) (black); colchicine (5 μM) (brown); 41 (5 μM) (blue), 41 (10 μM) (red); 43 (5 μM) (green), 43 (10 μM) (purple). (B) Compounds 41 and 43 arrested human melanoma A375 and human prostate cancer PC-3 cells in G2/M phase in vitro (N = 3).