Table 2. Half-Lives in Human (HLM) and Mouse (MLM) Liver Microsomes.
t1/2 (min) |
|||
---|---|---|---|
compd ID | HLM | MLM | |
class I | 2 | 38.9 ± 3.4 | 2.1 ± 1.1 |
13 | 30.7 ± 2.6 | 2.0 ± 0.8 | |
class II | 41 | 33.1 ± 4.8 | 10.5 ± 1.8 |
42 | 45.4 ± 3.0 | 16.1 ± 4.4 | |
43 | 56.3 ± 2.3 | 27.7 ± 6.1 |