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. 2014 Dec 22;34(37):4808–4820. doi: 10.1038/onc.2014.404

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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STIM1 promoted CRC cells invasion and metastasis in vivo. SW480 cells transfected with the LV-STIM1 expression vector (two clones, c1 and c2) or the control vector and SW620 cells transfected with LV-STIM1si-1, LV-STIM1si-2 or a negative control were injected into nude mice via the tail vein for an in vivo metastasis assay. Animals were killed 6 weeks after injection (a). Incidence of lung and liver metastasis in each group of nude mice. (b) Number of metastatic lung foci observed in each group. (b2) Number of metastatic liver foci observed in each group. (c1) Images showing representative hematoxylin and eosin staining of lung tissue samples from the different experimental groups. (c2) Images showing representative hematoxylin and eosin staining of liver tissue samples from the different experimental groups. Scale bar, 50 μm.