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. 2015 May 20;40(11):2489–2498. doi: 10.1038/npp.2015.108

Table 4. Medication Side Effects.

  Placebo Naltrexone
Gastrointestinal upset 16 76
Headache 8 24
Jittery/restless 9 23
Fatigue 25 30
Muscle ache 9 4
Lightheaded/dizzy 2 7
Increased urination 10 0
Increased heart Rate 2 7

Frequency of each symptom was reported over the 16 days of daily medication administration (symptoms occurring >6 times are portrayed). In the naltrexone group, 83% of participants reported at least one side effect as compared with 57% of the placebo group (χ12=3.80, p=0.051).