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. 2015 May 20;40(11):2614–2622. doi: 10.1038/npp.2015.109

Figure 3.

Figure 3

Effect of MOR agonists on Giα-coupling in vitro. (a and b) Effects of DAMGO, fentanyl (FENT), buprenorphine (BUP), morphine (MS), oxycodone (OXY), and hydrocodone (HYD) on Giα-coupling in HEK293 cells expressing either h/mOPRM1-118A (a) or 118G (b) receptors (EC50, nM, in parentheses) measured by inhibition of isoproterenol-stimulated cAMP synthesis. (c) Linear regression of transduction coefficients (log(T/KA)) for each agonist normalized to DAMGO (Δlog(T/KA); n=4, 0.3–10.0 ng transfected DNA/experiment). Dashed line indicates 95% confidence interval of regression line. Values represent mean±SEM.