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. 2015 May 13;40(11):2499–2509. doi: 10.1038/npp.2015.112

Figure 3.

Figure 3

L-655,708 rapidly reverses loss of sucrose preference after chronic unpredictable stress (CUS) but does not affect behavior in the open-field test. (a) Quantification of results from sucrose preference tests at three time points: before CUS, after 4 weeks of CUS and a vehicle injection given 24 h earlier, and after an additional week of CUS and an injection of L-655,708 given 24 h earlier. Mean sucrose preference differed significantly in the CUS+vehicle group compared with all other groups (F(2,8)=8.66, p=0.01, Tukey's test, n=5 rats). *p<0.05 compared with pre-CUS baseline, Bonferroni post hoc test. In the open-field test, there was no significant difference between unstressed rats given an injection of vehicle or L-655,708 (n=6 rats each) 30 min earlier in either total number of line crossings (b), an indicator of locomotor activity, or in crossings to the center of the arena (c), an indicator of anxiety.