Figure 5.

Correlation of changes in social interaction and sucrose preference behaviors after chronic stress and after administration of α5-preferring negative allosteric modulators. Changes from baseline responses in the social interaction and sucrose preference tests in response to either chronic restraint stress (CRS) or chronic unpredictable stress (CUS) in individual rats are shown in black. Changes from CRS/CUS responses in the social interaction and sucrose preference tests in response to injection of either L-655,708 or MRK-016 24 h earlier in individual rats are shown in gray. There was a strong correlation for both behavioral outcomes (linear fit in black; r=0.69; t(25)=4.781, p=0.0001; n=27).