Table 2.

Mean (standard error) baseline neurocognitive characteristics of older HIV+ individuals grouped by incident HIV-associated neurocognitive disorder.

Neurocognitive Domain T-scores	Normal (n = 47)	Incident HAND (n = 9)	p	g	AUC	Sens	Spec	PPV	NPV	Odds Ratio [95% CI]
Diagnostic Battery Measures
Learning	57.0(1.2)	50.6(2.5)	0.029	0.80	0.75	0.89	0.62	0.31	0.97	12.89 [2.11, 249.44]
Memory	56.2(1.1)	49.4(1.8)	0.013	1.04	0.77	0.78	0.75	0.37	0.95	10.21 [2.13, 75.20]
Attention	51.3(1.3)	45.6(2.5)	0.075	0.65	0.70	0.56	0.85	0.42	0.91	7.14 [1.55, 35.98]
Executive Functions	52.2(1.1)	43.5(2.5)	0.001	1.18	0.81	0.89	0.70	0.36	0.97	18.86 [3.05, 367.08]
Speed of Information Processing	50.5(0.9)	44.5(1.4)	0.005	1.05	0.80	0.89	0.62	0.31	0.97	12.89 [2.11, 249.44]
Motor Skills	46.7(1.1)	43.4(2.3)	0.243	0.42	0.61	0.44	0.83	0.33	0.89	3.9 [0.82, 18.25]
Supplementary Measures
Cognitive Reservea	51.5(1.0)	42.0(2.3)	0.001	1.33	0.84	0.56	1.00	1.00	0.92	116.11 [5.49, 2457.25]
Verbal Fluencya	51.5(1.2)	42.6(2.0)	0.003	1.13	0.83	1.00	0.66	0.36	1.00	36.27 [1.98, 662.92]
Semantic Memory	54.2(1.3)	48.4(2.1)	0.065	0.68	0.71	0.89	0.51	0.26	0.96	8.34 [1.37, 161.15]
Prospective Memoryab	51.5(1.4)	42.3(2.6)	0.010	0.96	0.78	0.78	0.79	0.41	0.95	12.95 [2.66, 96.69]

Note. HAND = HIV-associated Neurocognitive Disorder; g = Hedge’s g; AUC = Area under the curve; Sens = Sensitivity; Spec = Specificity; PPV = Positive predictive value; NPV = Negative predictive value. Values reflect normatively-adjusted T-scores unless otherwise indicated; Cutoff T-scores (Youden’s index): Learning = 54.83; Memory = 50.00; Attention = 41.00; Speed of Information Processing = 49.00; Executive Functions = 48.83; Motor Skills = 39.50; Cognitive Reserve = 37.90; Verbal Fluency = 48.63; Semantic Memory = 52.67; Prospective Memory = 43.85.

^aT-scores based on unadjusted sample-based mean and standard deviation of the older HIV+ sample.

^bMemory for Intentions Screening Test (MIST) Summary Score.