Table 2.
Melanoma SLN CD4+ T helper cell gene expression of particular interest to Th1 and Th2 function
| Gene name | Fold change | Function | ||
|---|---|---|---|---|
| Increased expression | ||||
| IL-13R | 20.28 | Receptor for IL-13 | ||
| TGFB3 | 15.33 | Inhibitory cytokine produced by regulatory T cells | ||
| STAT6 | 10.94 | Downstream mediator of IL-4 signaling | ||
| STAT4 | 9.43 | Th1 signaling | ||
| TNF | 7.48 | Chronic exposure impairs T cell activation | ||
| CCR4 | 6.36 | Preferentially expressed by Th2 cells | ||
| CCR2 | 6.17 | Chemokine for monocyte infiltration | ||
| IL-13 | 4.93 | Th2 cytokine | ||
| IL-6R | 4.66 | Th2 cytokine | ||
| CD40LG | 4.26 | Co-stimulatory and regulates B cell function | ||
| IL-17A | 3.83 | Chronic inflammatory cytokine | ||
| CREBBP | 3.79 | Th2 transcription factor | ||
| NFATC1 | 3.64 | Th2 transcription factor | ||
| CCR5 | 3.55 | Potentiates interaction between T cell and APC | ||
| NFATC2 | 3.43 | Th2 transcription factor | ||
| CSF2 | 3.32 | Stimulates granulocytes and monocytes | ||
| IL-4 | 3.05 | Th2 cytokine | ||
| Decreased expression | ||||
| CCL5 | 0.12 | Migration of Th1 T cells | ||
| SOCS2 | 0.13 | negative regulator of Th2 polarity | ||
| TLR6 | 0.18 | Drives Th1 response | ||
| IL-12B | 0.19 | Th1 cytokine | ||
| IRF4 | 0.21 | maintains Th1 polarity | ||
| IFNγ | 0.27 | Th1 cytokine | ||
| SOCS1 | 0.29 | maintains Th1 polarity | ||
| CD4 | 0.31 | T helper cell expression | ||