Table 3.
Immune cell phenotype of the control lymph node, non-SLN and SLN. Mean and standard deviation is reported. Due to multiple comparisons only a p-value ≤ 0.008 is considered statistically significant (Bonferroni correction).
| Immune cell type | Control LN | Non-SLN | SLN | Control vs. Non-SLN p value | Non-SLN vs. SLN p value | Control vs. SLN p value |
|---|---|---|---|---|---|---|
| CD3+ CD8+ (effector T cell) | 19.51 ± 7.36 | 15.74 ± 7.93 | 9.22 ± 4.98 | ns | 0.005 | 0.0005 |
| CD3+ CD62L+ (naive T cell) | 9.19 ± 10.52 | 26.82 ± 23.27 | 32.42 ± 15.43 | ns | ns | 0.0002 |
| CD3+ CD69+ (activated T cell) | 16.86 ± 13.38 | 17.63 ± 7.38 | 17.21 ± 10.72 | ns | ns | ns |
| CD3+ CD152 (CTLA-4) | 7.62 ± 5.90 | 7.38 ± 5.51 | 7.79 ± 3.32 | ns | ns | ns |
| CD3+ CD279 (PD-1) | 0.78 ± 0.93 | 2.25 ± 1.31 | 2.20 ± 1.13 | 0.005 | ns | 0.004 |
| CD11c+ CD86+ (mature dendritic cell) | 9.74 ± 8.70 | 7.59 ± 7.82 | 8.01 ± 6.29 | ns | ns | ns |
| CD141+ CD86+ (myeloid dendritic cell) | 23.91 ± 12.32 | 13.32 ± 15.78 | 15.02 ± 6.01 | ns | ns | ns |
| CD123+ (plasmacytoid dendritic cell) | 6.62 ± 8.79 | 3.49 ± 2.74 | 14.74 ± 18.35 | ns | ns | ns |
| CD20+ (B cell) | 20.73 ± 2.76 | 27.63 ± 2.85 | 31.14 ± 5.40 | s | ns | 0.008 |
| CD14+ (Macrophage) | 7.72 ± 5.56 | 12.69 ± 10.09 | 22.66 ± 18.70 | ns | ns | 0.009 |
| CD68+ (macrophage) | 2.70 ± 1.79 | 5.12 ± 3.58 | 9.26 ± 6.79 | ns | ns | 0.001 |
| CD4+ CD25+ FOXp3+ (Treg) | 25.38 ± 13.04 | 51.12 ± 26.39 | 35.1 ± 20.97 | 0.007 | ns | ns |