Table 2.
Dendritic cell (DC)-mediated γδ T cell activation
| DC-type | Culturing conditions | Effect on γδ T cells | Reference |
|---|---|---|---|
| MHC class II cells (DC) | + HMBPP or IPP | (+) proliferation | 47 |
| Blood DC | – | (+) proliferation | 41 |
| CD56+ blood DC | + zoledronate | (+) proliferation (+) IFN-γ, TNF-α and IL-1β |
10 |
| DC | CD34+-derived | (+) proliferation | 42 |
| Immature mo-DC | GM-CSF + IL-4 | (−) proliferation | 44,48 |
| GM-CSF + IL-4 + BrHPP | (−) cytotoxicity | 43 | |
| GM-CSF + IL-4 + zoledronate | (+) proliferation | 44 | |
| GM-CSF + IL-4 + zoledronate | (+) IFN-γ and TNF-α | 9 | |
| GM-CSF + IL-4 + zoledronate | (+) killing THP-1 | 48 | |
| Mature mo-DC | GM-CSF + IL-4 – IL-1β + TNF-α | (−) proliferation | 44 |
| GM-CSF + IL-4 – IL-1β + TNF-α + zoledronate | (+) proliferation (+) αβ T cell activation |
44 | |
| GM-CSF + IL-4 – TNF-α + IL-1β + IL-6 + PGE2 | (−) IFNγ, TNF-α | 9 | |
| GM-CSF + IL-4 – TNF-α + IL-1β + IL-6 + PGE2 + zoledronate | (+) proliferation tumor-antigen specific CD8+ T cells | 66 | |
| GM-CSF + IL-4 – TNF-α + IL-1β + IFN-α + IFN-γ + poly(I:C) | (+) IFN-γ, TNF-α (+) IL-10 |
9 | |
| GM-CSF + IL-4 – MPLA + IFN-γ | (+) IFN-γ, TNF-α | 9 | |
| GM-CSF + IL-4 – TLR-matured | (+) killing Daudi | 9 | |
| GM-CSF+ IL-4 – LPS | (−) killing myeloma cells | 51 | |
| GM-CSF+ IL-4 – LPS + high dose IL-2 | (+) proliferation | 51 | |
| GM-CSF+ IL-4 – LPS + low and high dose IL-15 | (+) proliferation | 51 | |
| GM-CSF+ IL-4 – LPS + ibandronate | (+) IFN-γ, TNF-α (−) killing myeloma cells |
51 | |
| GM-CSF+ IL-4 – LPS + TNF-α | (−) cytotoxicity | 43 | |
| GM-CSF+ IL-4 – LPS + TNF-α + pamidronate | (+) IFN-γ, TNF-α | 43 | |
| GM-CSF + IL-4 – KLH + IFN-γ + LPS | (−) proliferation CD4+ and CD8+ T cells | 67 | |
| GM-CSF + IFN-α | (+) proliferation tumor-specific CD8+ T cells | 65 | |
| Pathogen-infected DC | BCG-DC | (+) proliferation (+) IFN-γ and TNF-α (+) killing THP-1 |
48 |
| Brucella-DC | (+) proliferation CD4+ T cells | 37 | |
| MTB-DC | (+) proliferation | 49 | |
| HIV-DC | (−) proliferation | 50 | |
| pDC | R848-, CpG- or YF-17D-triggered | (+) IFN-γ | 60 |
Abbreviations: (+), stimulation of γδ T cell function; (−), no effect on γδ T cell function; BCG, Bacillus Calmette-Guérin; BrHPP, bromohydrin pyrophosphate; DC, dendritic cell; GM-CSF, granulocyte-macrophage colony-stimulating factor; HIV, human immunodeficiency virus; HMBPP, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate; IFN, interferon; IL, interleukin; IPP, isopentenyl pyrophosphate; KLH, keyhole limpet hemocyanin; LPS, lipopolysaccharide; MHC, major histocompatibility complex; mo-DC, monocyte-derived DC; MPLA, monophosphoryl lipid A; MTB, Mycobacterium tuberculosis; pDC, plasmacytoid dendritic cell; PG, prostaglandin; Poly(I:C), polyinosinic-polycytidylic acid; TLR, toll-like receptor; TNF, tumor necrosis factor; YF, yellow fever.