Figure 1.
Antitumor activity of 5-AZA-CdR combined with mAb 9H10 in the syngeneic TS/A mouse tumor model. BALB/c mice were inoculated sc with 2 × 105 TS/A cells. Groups of five mice were injected ip with 5-AZA-CdR on days 0, 7 (1st cycle) and 42, 49 (2nd cycle); with mAb 9H10 on days 2, 5, 8 (1st cycle) and 44, 47, 50 (2nd cycle); with combined administration of 5-AZA-CdR and mAb 9H10 according to the above reported schedules, or with saline solution for control. Tumor volumes from mice were measured periodically, all along the treatment. Mean tumor volume for each group are reported. Vertical arrows indicate days of different treatments. *, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001 vs. tumor volume of control group. †, p ≤ 0.05; ††, p ≤ 0.01 vs. tumor volume of 5-AZA-CdR group. Representative data are shown from three experiments.