Table 3.
Multivariable Adjusted OR of Hip Fracture Based on Quartiles of TNF-sR1 and TNFsR2
| n | Q1a | Q2a | Q3a | Q4a | P for Trend | |
|---|---|---|---|---|---|---|
| Model 1 | ||||||
| TNFα-sR1 | 396 | 1 | 1.77* (1.14, 2.74) | 1.67* (1.09, 2.56) | 2.27*** (1.45, 3.55) | .0011 |
| TNFα-sR2 | 391 | 1 | 1.41 (0.91, 2.20) | 1.48 (0.94, 2.31) | 2.10*** (1.36, 3.24) | .0010 |
| Model 2 | ||||||
| TNFα-sR1 | 396 | 1 | 1.74* (1.07, 2.82) | 1.86* (1.15, 2.98) | 3.11*** (1.87, 5.17) | <.0001 |
| TNFα-sR2 | 391 | 1 | 1.70* (1.03, 2.79) | 1.61 (0.97, 2.65) | 2.76*** (1.68, 4.51) | .0001 |
| Model 3 | ||||||
| TNFα-sR1 | 250 | 1 | 1.66 (0.84, 3.29) | 1.73 (0.86, 3.48) | 2.24* (1.05, 4.79) | .0475 |
| TNFα-sR2 | 245 | 1 | 1.92 (0.92, 3.98) | 1.91 (0.92, 3.97) | 2.83** (1.34, 5.99) | .0113 |
Data are expressed as OR (95% CI) obtained from logistic regression models. Quartile 1 is the reference stratum (OR = 1). “n” represents the number of case and control pairs used in the analysis; it varies due to missing covariate data. Model 1 is matched on age, race, year of enrollment, self-reported hormone use; no adjustment for other covariates. Model 2 is model 1 plus FRAX score. Model 3 is model 2 plus nutritional variables (intake of calcium, vitamin D, total energy, protein, multivitamin use), and factors impacting inflammation (NSAID use, arthritis, depression, body mass index, self-reported general health, comorbidity index, physical function, poor endurance/exhaustion, physical activity).
Interquartile cut-points for TNFα-sR1: 1246.0, 1465.2, and 1739.4 pg/mL; TNFα-sR2: 2674.4, 3118.4, and 3509.5 pg/mL (using controls only).
P < .05 relative to Q1;
P < .01;
P < .001. P values are from tests for linear trend.