Table 2.

Comparison of Adiponectin Concentrations in Controls (Non-DR) and Cases (DR) With Different Models of Covariate Adjustments

	Controls (n = 217)		Cases (n = 290)		P Value	Model	Covariates
	Meana	SEM	Mean	SEM
Adiponectin, μg/mL	10.29	0.78	12.97	1.04	.00003	2	Family structure, age, gender, BMI
	10.30	0.79	12.95	1.00	.0054	3	Family structure, age, gender, BMI, HbA1c, DM duration, statin use, SBP
	10.31	0.75	12.94	0.95	.0134	4	Model 3 plus Cr
	10.11	0.71	12.82	1.00	.0184	4	Model 3 plus ACR
	10.31	0.78	12.94	0.97	.0132	4	Model 3 plus eGFR

Abbreviations: DM, Diabetes Mellitus; SBP, Systolic Blood Pressure; Cr, creatinine; ACR, albumin to creatinine ratio. Models and significance, adjusting for: 1 = family structure; 2 = family structure, age, gender, BMI; 3 = family structure, age, gender, BMI, diabetes duration, statin use, systolic blood pressure, and HbA1c; and 4 = family structure, age, gender, BMI, diabetes duration, statin use, systolic blood pressure, HbA1c, and creatinine or albumin-to-creatinine ratio, or eGFR, respectively.

^aMean adiponectin concentrations, adjusted for covariates, in the different models.