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. 2015 Jul 20;100(9):3322–3331. doi: 10.1210/jc.2015-2332

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Copyright © 2015 by the Endocrine Society

This article has been published under the terms of the Creative Commons Attribution License (CC-BY; http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 1. — Patient flow diagram showing the number of patients assessed for eligibility, study enrolment, and kisspeptin-54 dose allocation. The study had a prospective adaptive design whereby the first 15 patients were randomly assigned 1:1:1 to receive kisspeptin-54 at doses of 3.2, 6.4, or 12.8 nmol/kg (n = 5 per group) to trigger oocyte maturation during IVF treatment. After interim analysis of oocyte maturation, subsequent patients were randomly assigned 1:1:1 to receive 6.4, 9.6, or 12.8 nmol/kg (n = 15 per group). No patients were lost to followup and no patients discontinued the intervention.