Table 2.
IVF Outcome Measures Following Kisspeptin-54 Trigger
| Outcome Measures | Kisspeptin-54 Dose (nmol/kg) |
||||
|---|---|---|---|---|---|
| 3.2 | 6.4 | 9.6 | 12.8 | All Doses | |
| n | 5 | 20 | 15 | 20 | 60 |
| No. of Oocytes | 8.8 (5.5) | 14.6 (11.1) | 11.9 (7.6) | 17.5 (10.9) | 14.4 (10.0) |
| No. of mature (M2) oocytes | 6.8 (5.6) | 11.6 (8.8) | 8.3 (6.3) | 14.1 (9.9) | 11.2 (8.6) |
| Oocyte maturation rate, %a | 62 (37) | 79 (21) | 66 (29) | 78 (24) | 74 (26) |
| Oocyte yield, %b | 53 (41) | 86 (49) | 86 (74) | 121 (119) | 95 (85) |
| No. of 2PN zygotes | 5.8 (4.8) | 9.4 (7.0) | 6.5 (5.6) | 11.1 (8.4) | 8.9 (7.2) |
| Fertilization rate, %c | 68 (39) | 76 (29) | 74 (33) | 73 (21) | 74 (28) |
| No. of patients with embryo transfer | 4 (80%) | 17 (85%) | 13 (87%) | 17 (85%) | 51 (85%) |
| No. of cleaved embryos at 3 d post ICSI | 5.8 (4.8) | 9.4 (7.0) | 6.5 (5.6) | 11.1 (8.4) | 8.9 (7.2) |
| No. of embryos at day 3 graded as 633 or above | 4.4 (3.0) | 6.6 (6.4) | 4.0 (3.0) | 6.9 (5.9) | 5.8 (5.4) |
| No. of patients with day 5 transfer | 4 (80%) | 15 (75%) | 11 (73%) | 17 (85%) | 47 (78%) |
| No. of embryos at day 5 | 5.6 (4.6) | 8.6 (7.3) | 6.1 (5.9) | 10.6 (7.9) | 8.4 (7.1) |
| No. of high-quality embryos (>3A/B) at day 5 | 1.6 (2.1) | 2.4 (2.9) | 1.1 (1.4) | 1.9 (2.5) | 1.8 (2.4) |
| No. of high-quality embryos (>3A/B) transferred | 0.8 (0.8) | 0.9 (0.8) | 0.7 (0.7) | 0.8 (0.7) | 0.8 (0.8) |
| Biochemical pregnancy rate per transfer, % | 50.0 | 64.7 | 84.6 | 47.1 | 62.7 |
| Clinical pregnancy rate per transfer, % | 25.0 | 58.8 | 76.9 | 35.3 | 52.9 |
| Implantation rate, %d | 25.0 (50.0) | 47.1 (45.0) | 57.7 (40.0) | 29.4 (43.5) | 42.2 (44.0) |
| Live birth rate per transfer, % | 25.0 | 52.9 | 61.5 | 29.4 | 45.1 |
Abbreviations. general comments, footnotes.
Data are presented as Means (SD) for continuous variables and Total (Percentages of N) for categorical variables.
a
Oocyte maturation rate is the percentage of oocytes collected which were mature.
b
Oocyte yield is the percentage of mature oocytes collected from the number of follicles ≥ 14 mm in diameter on the final ultrasound scan prior to kisspeptin-54 trigger administration.
c
Fertilization rate is the percentage of mature oocytes that fertilize following intracytoplasmic injection with sperm (ICSI).
d
Implantation rate is defined as the percentage of embryos transferred that implant on assessment by ultrasound at 6 wk of gestation.