Table 3.
Sensitivity (95% CI) of Diagnostic Techniques in Primary Source Localization According to Tumor Site
| Site (Positive Finding) | CT + | MRI + | OCT + | FDG-PET + | F-DOPA-PET + | MIBG + | 68Gallium-SSTR-PET/CT + |
|---|---|---|---|---|---|---|---|
| Lung | 79.4% (70.3–86.2) | 66.7% (48.8–80.8) | 60.9% (50.2–70.8) | 54.6% (38.0–70.2) | 71.4% (45.4–88.3) | 50% (9.5–90.6) | 77.8% (45.3–93.7) |
| n | 77/97 | 20/30 | 50/82 | 18/33 | 10/14 | 1/2 | 7/9 |
| Thymus, mediastinum | 85% (63.9–94.8) | 62.5% (30.6–86.3) | 85.7% (60.1–96.0) | 62.5% (30.6–86.3) | 33.3% (6.2–79.2) | nd | 50% (15.0–85.0) |
| n | 17/20 | 5/8 | 12/14 | 5/8 | 1/3 | 2/4 | |
| Pancreas | 85.7% (60.1–96.0) | 87.5% (52.9–97.8) | 66.7% (35.4–88) | 100% (61–100) | nd | Out of 1 case: 0 TP, 1 FN | 100% (34.2–100) |
| n | 12/14 | 7/8 | 6/9 | 6/6 | 2/2 | ||
| Adrenal gland | 100% (72–100) | 100% (57–100) | 60% (23.1–88.2) | 100% (44–100) | 100% (20.7–100) | 50% (15–85) | nd |
| n | 10/10 | 5/5 | 3/5 | 3/3 | 1/1 | 2/4 | |
| Gastrointestinal tract | 90% (59.6–98.2) | 71.4% (35.9–91.8) | 50% (21.5–78.5) | 57.1% (25.1–84.2) | 100% (20.7–100) | nd | 100% (34.2–100) |
| n | 9/10 | 5/7 | 4/8 | 4/7 | 1/1 | 2/2 | |
| Thyroid | 80% (37.6–96.4) | 100% (20.7–100) | 66.7% (20.8–93.9) | 100% (43.9–100) | nd | Out of 3 cases: 0 TP, 1 FP, 2 FN | 100% (34.2–100) |
| n | 4/5 | 1/1 | 2/3 | 3/3 | 2/2 | ||
| Carotid glomus, atrium, para-aortic region | 33.3% (6.2–79.2) | 33.3% (6.2–79.2) | 80% (37.6–96.4) | 100% (34.2–100) | nd | nd | nd |
| n | 1/3 | 1/3 | 4/5 | 2/2 | |||
| Head: ethmoidal-paranasal-sphenoid- sinus, olfactory bulb, skull base, etc | 57.1% (25.1–84.2) | 87.50% (52.9–97.8) | 80% (37.6–96.4) | 71.4% (35.9–91.8) | Out of 1 case: 0 TP, 1 FN | nd | 100% (43.9–100) |
| n | 4/7 | 7/8 | 4/5 | 5/7 | 3/3 | ||
| Abdomen/other (abdominal paraganglioma, ovary) | 60% (23.1–88.2) | 66.7% (20.8–93.9) | 20% (3.6–62.5) | 100% (20.7–100) | nd | 100% (34.2–100) | nd |
| n | 3/5 | 2/3 | 1/5 | 1/1 | 2/2 |
Abbreviations: TP, true positive; FP, false positive; FN, false negative; nd, not done; +, positive. Data are expressed as percentage (95% CI), unless stated otherwise.