Table 2.
Serum T PK Parameters After Transdermal T Gel Application in Older Men
| T PK Parameters (mean ± SEM) | T Gel (n = 27) | Placebo Gel (n = 20) |
|---|---|---|
| Cavg0–24, ng/dL | 453 ± 178a | 182 ± 34 |
| Cmax, ng/dL | 680 ± 297 | 230 ± 40 |
| Cmin, ng/dL | 281 ± 143 | 134 ± 18 |
| Tmax, h | 9.7 ± 9.1 | 17.3 ± 9.0 |
| Fluctuation, % | 88 ± 42 | 52 ± 18 |
Abbreviations: Cavg0–24, area under the 24-hour T concentration curve (AUC0–24) divided by 24 hours; fluctuation index (a summary of variability), (Cmax − Cmin)/Cavg; Tmax, time to reach Cmax.
a
Serum T in nanograms per deciliter = 0.03 467 nmol/L.