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Patients with truncating vs nontruncating AIPmuts. Patients with truncating AIPmuts present with a more aggressive phenotype, characterized by an earlier age at onset (A) (P = .005) and (B) at diagnosis (P = .003). C, This earlier disease onset results in a higher frequency of pediatric cases (n [total] = 131); in fact, most of the patients with truncating mutations present in childhood and adolescence. **, P < .01.
