Table 1.
Screen hit genes. siRNA that show inhibition of aggresome in more than 30% of the cells and with more than two different sequences of the siRNA
| Symbol | Category | Entrez gene name |
|---|---|---|
| ABLIM1 | 8 | Actin-binding LIM protein 1 |
| ACTN4 | 8 | Actinin, alpha 4 |
| ACTR1A | 8 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) |
| ADD2 | 8 | Adducin 2 (beta) |
| AHSP | 7 | Alpha hemoglobin-stabilizing protein |
| AKAP11 | 8 | A kinase (PRKA) anchor protein 11 |
| APOM | 2 | Apolipoprotein M |
| ARHGAP9 | 8 | Rho GTPase-activating protein 9 |
| ARSG | 8 | Arylsulfatase G |
| ATG9A | 8 | ATG9 autophagy related 9 homolog A (S. cerevisiae) |
| BCL2L10 | 8 | BCL2-like 10 (apoptosis facilitator) |
| BMP7 | 8 | Bone morphogenetic protein 7 |
| BRF1 | 4,6 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) |
| BTF3 | 6 | Basic transcription factor 3 |
| C2orf66 | 8 | Chromosome 2 open reading frame 66 |
| CAD | 8 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| CCT4 | 7 | Chaperonin containing TCP1, subunit 4 (delta) |
| CCT8 | 7 | Chaperonin containing TCP1, subunit 8 (theta) |
| CDC40 | 1 | Cell division cycle 40 homolog (S. cerevisiae) |
| CDC5L | 1,3 | CDC5 cell division cycle 5-like (S. pombe) |
| CENPH | 3 | Centromere protein H |
| CLTB | 8 | Clathrin, light chain B |
| CORT | 8 | Cortistatin |
| CRNKL1 | 1 | Crooked neck pre-mRNA splicing factor-like 1 (Drosophila) |
| CSNK2B | 8 | Casein kinase 2, beta polypeptide |
| CWC15 | 1 | CWC15 spliceosome-associated protein homolog (S. cerevisiae) |
| CWC22 | 1 | CWC22 spliceosome-associated protein homolog (S. cerevisiae) |
| DDX24 | 8 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 |
| DHX8 | 1 | DEAH (Asp-Glu-Ala-His) box polypeptide 8 |
| DYNC1H1 | 3,5 | Dynein, cytoplasmic 1, heavy chain 1 |
| DYNC1I2 | 5 | Dynein, cytoplasmic 1, intermediate chain 2 |
| EFTUD2 | 1 | Elongation factor Tu GTP binding domain containing 2 |
| EIF3D | 4 | Eukaryotic translation initiation factor 3, subunit D |
| EXOSC8 | 1 | Exosome component 8 |
| FAM135B | 8 | Family with sequence similarity 135, member B |
| FGF12 | 8 | Fibroblast growth factor 12 |
| GAS2 | 3 | Growth arrest-specific 2 |
| GIMAP5 | 8 | GTPase, IMAP family member 5 |
| GPR12 | 8 | G protein-coupled receptor 12 |
| GPR153 | 8 | G protein-coupled receptor 153 |
| GRB14 | 8 | Growth factor receptor-bound protein 14 |
| GRIK3 | 8 | Glutamate receptor, ionotropic, kainate 3 |
| HGS | 8 | Hepatocyte growth factor-regulated tyrosine kinase substrate |
| HIST1H3A | 8 | Histone cluster 1, H3a |
| HNRNPC | 1 | Heterogeneous nuclear ribonucleoprotein C (C1/C2) |
| HNRNPK | 1 | Heterogeneous nuclear ribonucleoprotein K |
| HOXB8 | 8 | Homeobox B8 |
| HSPA8 | 7 | Heat-shock 70 kDa protein 8 |
| IGLL1 | 8 | Immunoglobulin lambda-like polypeptide 1 |
| IGSF10 | 8 | Immunoglobulin superfamily, member 10 |
| IL17A | 8 | Interleukin 17A |
| INTS4 | 1 | Integrator complex subunit 4 |
| IRF3 | 6 | Interferon regulatory factor 3 |
| ISY1 | 1 | ISY1 splicing factor homolog (S. cerevisiae) |
| KIF20A | 5 | Kinesin family member 20A |
| KRT81 | 8 | Keratin 81 |
| LEPROT | 8 | Leptin receptor overlapping transcript |
| LOC286149 | 8 | Hypothetical protein LOC286149 |
| LRP8 | 8 | Low-density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
| LTBR | 8 | Lymphotoxin beta receptor (TNFR superfamily, member 3) |
| MAF1 | 8 | MAF1 homolog (S. cerevisiae) |
| MAK16 | 8 | MAK16 homolog (S. cerevisiae) |
| MC3R | 8 | Melanocortin 3 receptor |
| MFAP1 | 8 | Microfibrillar-associated protein 1 |
| MOBKL2A | 8 | MOB1, Mps One Binder kinase activator-like 2A (yeast) |
| MUSTN1 | 8 | Musculoskeletal, embryonic nuclear protein 1 |
| MYST1 | 4 | MYST histone acetyltransferase 1 |
| NACA | 4 | Nascent polypeptide-associated complex alpha subunit |
| NCKAP5L | 8 | NCK-associated protein 5-like |
| NEK11 | 3 | NIMA (never in mitosis gene a)- related kinase 11 |
| NLE1 | 8 | Notchless homolog 1 (Drosophila) |
| ODC1 | 4 | Ornithine decarboxylase 1 |
| PABPN1 | 1 | Poly(A) binding protein, nuclear 1 |
| PAFAH1B1 | 5,3 | Platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45 kDa) |
| PANK4 | 8 | Pantothenate kinase 4 |
| PAXIP1 | 8 | PAX interacting (with transcription-activation domain) protein 1 |
| PCNT | 3,5 | Pericentrin |
| PDE8B | 8 | Phosphodiesterase 8B |
| PGBD3 | 8 | PiggyBac transposable element derived 3 |
| PHF5A | 1 | PHD finger protein 5A |
| POLR2F | 1,6 | Polymerase (RNA) II (DNA directed) polypeptide F |
| POLR2G | 1,6 | Polymerase (RNA) II (DNA directed) polypeptide G |
| PRODH2 | 8 | Proline dehydrogenase (oxidase) 2 |
| PRPF18 | 1 | PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) |
| PRPF31 | 1 | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) |
| PRPF40A | 1 | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) |
| PRPF4B | 1 | PRP4 pre-mRNA processing factor 4 homolog B (yeast) |
| PSMA1 | 2,3 | Proteasome (prosome, macropain) subunit, alpha type, 1 |
| PSMA5 | 2,3 | Proteasome (prosome, macropain) subunit, alpha type, 5 |
| PSMA7 | 2,3 | Proteasome (prosome, macropain) subunit, alpha type, 7 |
| PSMB1 | 2,3 | Proteasome (prosome, macropain) subunit, beta type, 1 |
| PSMB3 | 2,3 | Proteasome (prosome, macropain) subunit, beta type, 3 |
| PSMC1 | 2,3 | Proteasome (prosome, macropain) 26S subunit, ATPase, 1 |
| PSMC3 | 2,3 | Proteasome (prosome, macropain) 26S subunit, ATPase, 3 |
| PSMC6 | 2,3 | Proteasome (prosome, macropain) 26S subunit, ATPase, 6 |
| PSMD1 | 2,3 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 |
| PSMD3 | 2,3 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 |
| PTGR1 | 8 | Prostaglandin reductase 1 |
| PTK2 | 5 | PTK2 protein tyrosine kinase 2 |
| PUS7 | 1 | Pseudouridylate synthase 7 homolog (S. cerevisiae) |
| PVRL3 | 8 | Poliovirus receptor-related 3 |
| RASSF4 | 3 | Ras association (RalGDS/AF-6) domain family member 4 |
| RPL13 | 4 | Ribosomal protein L13 |
| RPL21 | 4 | Ribosomal protein L21 |
| RPL3 | 4 | Ribosomal protein L3 |
| RPL4 | 4 | Ribosomal protein L4 |
| RPL8 | 4 | Ribosomal protein L8 |
| RPLP2 | 4 | Ribosomal protein, large, P2 |
| RPP25 | 1 | Ribonuclease P/MRP 25 kDa subunit |
| RRM1 | 1,6 | Ribonucleotide reductase M1 |
| RSL24D1 | 4 | Ribosomal L24 domain containing 1 |
| RUVBL1 | 3,4 | RuvB-like 1 (E. coli) |
| RUVBL2 | 3,4 | RuvB-like 2 (E. coli) |
| SALL1 | 8 | Sal-like 1 (Drosophila) |
| SAP30BP | 8 | SAP30 binding protein |
| SART1 | 1,3 | Squamous cell carcinoma antigen recognized by T cells |
| SETD8 | 3 | SET domain containing (lysine methyltransferase) 8 |
| SF3A1 | 1 | Splicing factor 3a, subunit 1, 120 kDa |
| SF3A2 | 3 | Splicing factor 3a, subunit 2, 66 kDa |
| SF3A3 | 3 | Splicing factor 3a, subunit 3, 60 kDa |
| SF3B1 | 3 | Splicing factor 3b, subunit 1, 155 kDa |
| SF3B14 | 3 | Splicing factor 3B, 14 kDa subunit |
| SF3B2 | 3 | Splicing factor 3b, subunit 2, 145 kDa |
| SF3B3 | 3 | Splicing factor 3b, subunit 3, 130 kDa |
| SF3B4 | 3 | Splicing factor 3b, subunit 4, 49 kDa |
| SF3B5 | 3 | Splicing factor 3b, subunit 5, 10 kDa |
| SHB | 8 | Src homology 2 domain containing adaptor protein B |
| SLC25A10 | 8 | Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 |
| SLC48A1 | 8 | Solute carrier family 48 (heme transporter), member 1 |
| SLC9A3R2 | 8 | Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 |
| SMARCB1 | 3 | SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b |
| SNCAIP | 1 | Synuclein, alpha interacting protein |
| SNRNP200 | 1 | Small nuclear ribonucleoprotein 200 kDa (U5) |
| SNRNP70 | 1 | Small nuclear ribonucleoprotein 70 kDa (U1) |
| SNRPA1 | 1 | Small nuclear ribonucleoprotein polypeptide A' |
| SNRPB | 1 | Small nuclear ribonucleoprotein polypeptides B and B1 |
| SNRPC | 1 | Small nuclear ribonucleoprotein polypeptide C |
| SNRPD1 | 1 | Small nuclear ribonucleoprotein D1 polypeptide 16 kDa |
| SNRPD2 | 1 | Small nuclear ribonucleoprotein D2 polypeptide 16.5 kDa |
| SNRPD3 | 1 | Small nuclear ribonucleoprotein D3 polypeptide 18 kDa |
| SNRPE | 1 | Small nuclear ribonucleoprotein polypeptide E |
| SSPO | 8 | SCO-spondin homolog (Bos taurus) |
| STK11 | 3 | Serine/threonine kinase 11 |
| SUGP1 | 8 | SURP and G patch domain containing 1 |
| SUPT6H | 8 | Suppressor of Ty 6 homolog (S. cerevisiae) |
| TARDBP | 1,3,6 | TAR DNA binding protein |
| TCEB2 | 6 | Transcription elongation factor B (SIII), polypeptide 2 (18 kDa, elongin B) |
| TCP10 | 7 | T-complex 10 homolog (mouse) |
| TRHR | 8 | Thyrotropin-releasing hormone receptor |
| TUBB | 3,5 | Tubulin, beta |
| U2AF1 | 1 | U2 small nuclear RNA auxiliary factor 1 |
| U2AF2 | 1 | U2 small nuclear RNA auxiliary factor 2 |
| USP9X | 3 | Ubiquitin specific peptidase 9, X-linked |
| VPRBP | 8 | Vpr (HIV-1) binding protein |
| XAB2 | 1 | XPA binding protein 2 |
| ZNF124 | 8 | Zinc finger protein 124 |
| ZNF233 | 8 | Zinc finger protein 233 |
| ZNF679 | 8 | Zinc finger protein 679 |
| ZNF691 | 8 | Zinc finger protein 691 |
Genes categorized to biological process groups #1—RNA processing, #2—Proteasome-ubiquitin system, #3—Cell cycle, #4—Translation, #5—Microtubules-based process, #6—Transcription, #7—Unfolded protein binding, #8—Uncategorized.