Table I.
Structural Data, Conserved Residues of Catalytic Importance, and Activity Classification of Type-3 Copper Proteins
| Protein | Organism | PDB | Thioether bond | Placeholder | Blocker residue | Conserved Met | Conserved water | Conserved Glu/Asn | Activitya | References |
|---|---|---|---|---|---|---|---|---|---|---|
| Tyrosinase (TyrSc) | Streptomyces castaneoglobisporus | 1WX2b | No | Tyr98 (caddie) | Gly204 | Met201 | HOH431 | Glu182 Asn191 | ++ | Matoba et al., (2006)16 |
| Tyrosinase (TyrBm) | Bacillus megaterium | 3NM8b | No | No | Val218 | Met215 | HOH376 | Glu195 Asn205 | ++ | Sendovski et al., (2010)17 |
| Tyrosinase (PPOVv) | Vitis vinifera | 2P3X | Yes | Cleaved | Phe259 | Met256 | No | Glu235 Asn240 | ++ | Virador et al., (2010)55 |
| Tyrosinase (abPPO3) | Agaricus biporus | 2Y9Xb | Yes | Cleaved | Val283 | Met280 | HOH2095 | Glu256 Asn260 | ++ | Ismaya et al., (2011)44 |
| Tyrosinase (abPPO4) | Agaricus biporus | 4OUA | Yes | Phe454 | Ala270 | Met267 | HOH527 | Glu248 Asp252 | ++ | Mauracher et al., (2014)31 |
| Tyrosinase (TyrAo) | Asperugillus oryzae | 3W6Qb | Yes | Phe513 | Val359 | Met356 | HOH1103 | Glu325 Asn329 | ++ | Fujieda et al., (2013)32 |
| Catechol oxidase (IbCO) | Ipomoea batatas | 1BT3b | Yes | Cleaved | Phe261 | Met258 | HOH1007 | Glu236 Ile241 | + | Klabunde et al., (1998)8 |
| Catechol oxidase (AoCO4) | Asperugillus oryzae | 4J3Pb | No | No | Val299 | Met291 | HOH2198 | Gln273 Gly285 | + | Hakulinen et al., (2013)26 |
| Pro-phenoloxidase (proPOMc) | Manduca sexta | 3HHS | No | Phe85/Phe88 | Ser393/Glu395 | Met390 | HOH781 HOH700 | Glu351/353 Asn367/369 | ++ | Li et al., (2009)51 |
| Pro-phenoloxidase (proPOc) | Marsupenaeus japonicus | 3WKY | No | Phe72 | Val384 | Met381 | HOH831 | Glu343 Asn358 | ++ | Masuda et al., (2014)46 |
| Hemocyanin (Lobster Hc) | Panulirus interruptus | 1HCYb | No | Phe75 | Phe371 | Met368 | HOH779 | Glu329 Asn345 | + | Volbeda et al., (1989)47 |
| Hemocyanin (Crab Hc) | Limulus polyphemus | 1NOLb | No | Phe49 | Thr351 | Met348 | HOH662 | Glu309 Asn325 | ++ | Magnus et al., (1993)7 |
| Hemocyanin (Octopus Hc) | Octopus | 1JS8 | Yes | Leu2830 | Leu2689 | Met2686 | HOH436 | Glu2668 Asn2672 | ++ | Cuff et al., (1998)42 |
| Hemocyanin (Rapana Hc) | Rapana thomasiana | 1LNL | Yes | Leu343 | Leu199 | Met196 | No water molecules in the structure | Glu178 Asn182 | + | Perbandt et al., (2003)43 |
a
(+) denotes diphenolase activity only, (++) denotes mono- and diphenolase activity.
b
Several structures were deposited in PDB.