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Superposition of the centroids of most populated clusters found from the MD simulations of 4E-BP and 4G peptides and the BEDAM simulation of CYFIP1p complexed with eIF4E. The helix axial rotation (A) and tilt (B) of the CYFIP1 peptide (dark gray) relative to the reference 1WKW structure of 4E-BP1 are indicated. Color code as in Figure 2. C: Detail of the network of interactions established between CYFIP1p and eIF4E as predicted by the BEDAM model.
