Table II.

Residue-Residue Contacts Established Between the Peptides and eIF4E in the Computational Models

Peptide's residue	Position	eIF4E residue	Peptide's residue	Position	eIF4E residue
4E-BPs and eIF4G peptides			CYFIP1 peptide
					MD model	BEDAM model
Y	Y1	His37, Pro38, Leu39, Gly139	L	L1		Ile138, Gly139
D/S/G	X2		D	X2
R/P	X3	Glu132, Leu135, Arg186	K	K3	Asp143, Asp144	Glu132, Glu140
K/E/T	X4		R	R4
F	X5	His37	L	L5		Val69, Trp73, Ile138
L	L6	Val69, Trp73, Leu135, Ile138, Gly139	R	R6	Glu140, Ser141, Asp143	Glu132, Leu135
L/M	7	Trp73, Leu135	S	S7
D/E/G/Q	X8		E	E8
F/C/R	X9	Val69, Glu70, Trp73	C	C9		Trp73, Leu135
K/R/Q	X10	Trp73, Tyr76, Ile78, Glu128	K	K10
N/D/F	X11		N	N11

^aInteractions conserved among MD and X-ray or NMR structures are highlighted in bold.

Contacts occurring in more than 50% of the trajectory snapshots are listed. A contact is defined as an interatomic distance smaller than 4 Å.