Table II.

Binding Analysis of Rontalizumab for Interferons

interferon	ka (Ms−1)	kd (s−1)	KD (nM)
IFN-α2	2.02 × 106	3.71 × 10−5	0.018
IFN-α8	8.11 × 105	1.62 × 10−5	0.020
IFN-α5	1.07 × 106	3.37 × 10−5	0.031
IFN-α21	1.11 × 106	5.12 × 10−5	0.046
IFN-α17	9.91 × 105	3.24 × 10−4	0.33
IFN-α14	6.31 × 105	3.26 × 10−4	0.52
IFN-α16	1.31 × 106	9.42 × 10−4	0.72
IFN-α1	4.66 × 105	3.89 × 10−4	0.83
IFN-α7	1.88 × 105	2.43 × 10−4	1.3
IFN-α4	8.51 × 105	5.52 × 10−3	6.5
IFN-α6	8.94 × 105	9.76 × 10−3	10.9
IFN-α10	6.4 × 105	2.27 × 10−2	35.4
IFN-β	no binding