Table VI.

Difference in Solvent-Accessible Surface Area of Various Strands and Loops (measured in Ų) Between Amyloid and Native State of the Various REI Light-Chain Proteins Calculated Using the Last 50 ns of the Sampling Process and Averaged Over All Trajectories

	Amyloid form − Native form
	ΔSASA╪
Position	WT	R61N	G68D	D82I	A84T
1–13	37.36	21.99	24.44	9.91	7.86
14–18	14.17	1.62	−5.67	−15.95	2.90
19–25	−12.68	−15.77	−21.54	−18.14	−12.58
26–32	41.24	74.55	46.75	54.38	54.85
33–38	−17.66	2.94	−5.49	−13.12	3.62
39–44	−2.99	6.40	−1.27	36.86	0.72
45–49	11.28	10.37	−1.92	−11.21	8.74
50–54	22.64	17.72	1.77	−8.02	−5.23
55–61	0.50	8.59	−11.93	−8.18	6.70
62–68	−4.41	17.41	2.52	4.63	6.65
69–75	−2.40	19.51	0.16	0.18	1.26
76–84	43.88	53.10	−1.39	−124.35	23.96
85–90	−10.99	8.27	−14.75	−21.42	5.16
91–100	−5.58	−6.83	−10.25	7.08	−6.96
101–104	7.86	3.09	−6.18	−17.49	−11.40
105–107	27.97	2.58	−0.73	−8.68	−1.58

ΔSASA^╪ = SASA_amyloid − SASA_native.