Table 3.
List of potential hub genes that identified by the SPACE and SCPG methods
| SPACE |
SCPG |
||||||
|---|---|---|---|---|---|---|---|
| No. | Gene symbol | Degree | CR | No. | Gene symbol | Degree | CR |
| 1 | PRC1 | 39 | 1 | GPR116 | 18 | ||
| 2 | RRM2 | 18 | 2 | NKX2-1 | 18 |  |
|
| 3 | CYP2B7P1 | 17 | 3 | RRM2 | 18 | ||
| 4 | GPR116 | 17 | 4 | CTNNB1 | 17 |  |
|
| 5 | SFTPB | 17 |  |
5 | CYP2B7P1 | 17 | |
| 6 | NKX2-1 | 16 |  |
6 | CSNK2A1 | 16 |  |
| 7 | TFF1 | 16 | 7 | TFF1 | 15 | ||
| 8 | HOP | 15 |  |
8 | C1orf116 | 14 | |
| 9 | C1orf116 | 14 | 9 | HOP | 14 |  |
|
| 10 | FMO5 | 14 | 10 | SFTPB | 14 |  |
|
| 11 | CD302 | 12 | 11 | ESR1 | 13 |  |
|
| 12 | HSD17B6 | 12 | 12 | FMO5 | 12 | ||
| 13 | HOXD1 | 9 | 13 | CD302 | 11 | ||
| 14 | TMPRSS2 | 9 | 14 | NEDD9 | 11 |  |
|
| 15 | TPX2 | 9 | 15 | FYN | 10 |  |
|
| 16 | UBE2C | 8 |  |
16 | PTPN13 | 10 | |
| 17 | TYMS | 7 |  |
17 | BRCA1 | 9 |  |
| 18 | HSD17B6 | 9 | |||||
| 19 | PIK3R1 | 9 |  |
||||
| 20 | SLC34A2 | 9 | |||||
Bold font highlights the genes identified by both methods. “CR” denotes cancer-related genes identified by previous studies.