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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Biotechnol Bioeng. 2015 Jul 22;112(10):2185–2194. doi: 10.1002/bit.25622

Figure 2.

Figure 2

Activation of endometrial epithelial cell signal transduction pathways and VEGF production in CG scaffolds response to exogenous E2. (A) Estrogen receptor (ERα) activation at 5 min exposure to E2-supplemented media. (B) ERK 1/2 phosphorylation following 5 min treatment with (0–1000 nM E2) or 3–10 min exposure at 10 nM E2. (C) VEGF production by epithelial cells was found to be E2 dose dependent. ^Significantly higher VEGF production over other treatments *Significantly higher VEGF production compared to control (0 nM E2).