Table 4.

Effect of diuretics on association between PPI use and change in serum magnesium level

	Change in serum magnesium level (mg/dL)
	Control group	PPI group	P⁎
Loop diuretics (n = 69)	0.02±0.23	0.09±0.27	0.282⁎
Thiazide diuretics (n = 82)	0.01±0.11	0.03±0.22	0.801⁎
Potassium-sparing diuretics (n = 47)	0.05±0.25	−0.03±0.34	0.431⁎
Multiple (n = 96)	0.12±0.27	−0.01±0.25	0.025⁎
Loop + thiazide	0.10±0.42 (n = 2)	0.10±0.37 (n = 4)	0.999†
Loop + potassium sparing	0.12±0.20 (n = 15)	0.03±0.24 (n = 43)	0.188†
Thiazide + potassium sparing	0.10±0.4 (n = 8)	−0.18±0.24 (n = 13)	0.151†
More than 3 diuretic agents	0.17±0.06 (n = 8)	−0.13±0.22 (n = 13)	0.054†

Values are N, mean ± SD.

ANCOVA, analysis of covariance; PPI, proton pump inhibitor.

^⁎P value by ANCOVA.

^†P value by t test.