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. 2015 Sep 15;11:235. doi: 10.1186/s12917-015-0546-y

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© Spoerri et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Model results of relative gene expression (fold changes in mRNA levels, mean ± SE) of A ERα (ESR1), B PGR, C PRLR and D GHR in normal mammary tissue, benign and malignant neoplasms. The significant interaction for tissue group and reproductive state/cycle on CDH-1 gene expression is shown in (E,F); E Relative gene expression (RGE; fold changes in mRNA levels, mean ± SE) of CDH-1 in normal mammary tissue, benign and malignant mammary neoplasms of diestrous dogs; F Relative gene expression (RGE; fold changes in mRNA levels, mean ± SE) of CDH-1 in benign mammary neoplasms collected from spayed dogs, anestrous and diestrous bitches. Bars with different superscripts differ at p < 0.05