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. 2015 Sep 15;12:54. doi: 10.1186/s12950-015-0099-7

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© Peixoto and Gomes. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic diagram showing the hypothetical mechanism of Phosphodiesterase 5 Inhibitors (PDE5Is) on prostatic inflammmation. PDE5Is can direct and indirectly down-regulate prostatic inflammation/BPH/LUTS by inducing high levels of cGMP