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. 2015 Apr 25;34(2):83–92. doi: 10.1016/j.krcp.2015.03.005

Figure 8.

Figure 8

Effects of aldosterone on the activation of ERK1/2 and p38 MAPK in HPMCs with or without spironolactone pretreatment. Aldosterone (10nM) significantly increased phosphorylation of ERK1/2 (A) and p38 MAPK (B) in HPMCs. Aldosterone-induced activation of ERK1/2 and p38 MAPK was inhibited by spironolactone (1μM) (C, D). Representative western blotting and its quantitation graphs are shown (n=4). ⁎P<0.05 versus others. ERK, extracellular signal-regulated kinase; HMPC, human peritoneal mesothelial cell; MAPK, mitogen-activated protein kinase.