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. 2015 Apr 25;34(2):83–92. doi: 10.1016/j.krcp.2015.03.005

Figure 12.

Figure 12

Effect of antioxidants on aldosterone-induced MAPK activation. Aldosterone (10nM) significantly increased phosphorylation of ERK1/2 (A) and p38 MAPK (B) in human peritoneal mesothelial cells. Aldosterone-induced activation of ERK1/2 and p38 MAPK was significantly ameliorated by antioxidants, NAC (5mM) or apocynin (10μM). However, rotenone (5μM) did not alter the aldosterone-induced activation of ERK1/2 and p38 MAPK. Representative western blotting and its quantitation graphs are shown (n=4). ⁎P<0.05 versus others. Aldo, aldosterone; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; NAC, N-acetyl cysteine.