Table 3. Diagnostic characteristics of the 2004 ATP III and 2013 ACC/AHA guidelines in assigning statin therapy in subjects with subclinical coronary atherosclerosis.
| MDCT findings | N (%) | 2004 ATP III | 2013 ACC/AHA | P value* | P value † | ||
|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | Sensitivity | Specificity | ||||
| Significant stenosis | 432 (7.4%) | 33.8 (29.5–38.4) | 85.0 (84.1–86.0) | 61.8 (57.1–66.3) | 68.6 (67.4–69.9) | < .001 | < .001 |
| CACS>0 | 1945 (33.4%) | 25.5 (23.6–27.5) | 88.3 (87.2–89.3) | 54.7 (52.5–56.9) | 77.0 (75.7–78.3) | < .001 | < .001 |
| CACS>100 | 533 (9.2%) | 26.5 (22.9–30.4) | 84.7 (83.7–85.6) | 63.6 (59.4–67.6) | 69.4 (68.2–70.7) | < .001 | < .001 |
| Any plaque | 2330 (39.9%) | 24.7 (23.0–26.5) | 89.2 (88.1–90.2) | 52.3 (50.2–54.3) | 78.8 (77.4–80.1) | < .001 | < .001 |
| CAP | 1535 (26.3%) | 24.9 (22.8–27.1) | 86.7 (85.6–87.7) | 54.7 (52.2–57.2) | 73.9 (72.6–75.2) | < .001 | < .001 |
| NCAP | 1047 (17.9%) | 26.5 (23.9–29.2) | 85.8 (84.8–86.8) | 52.1 (49.0–55.1) | 70.4 (69.1–71.7) | < .001 | < .001 |
| MCAP | 493 (8.4%) | 32.0 (28.1–36.3) | 85.1 (84.1–86.0) | 67.3 (63.1–71.3) | 69.5 (68.2–70.7) | < .001 | < .001 |
95% Confidence intervals are in brackets. MDCT, multi-detector computed tomography; ATP, Adult Treatment Panel; ACC/AHA, American College of Cardiology / American Heart Association; CACS, coronary artery calcium scores; CAP, calcified plaque; NCAP, noncalcified plaque; MCAP, mixed plaque.
*P value for sensitivity.
† P value for specificity.