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. 2015 Sep 15;16:54. doi: 10.1186/s12865-015-0117-9

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© Al Ghamdi et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Altered proliferative capacity of B and T lymphocytes in diabetic mice supplemented with propolis. The proliferative capacity of B lymphocytes in response to stimulation with IL-4 and CD40L and of T lymphocytes in response to stimulation with SEB was evaluated using CFSE assays and flow cytometry. a Representative dot plots showing the gating strategy to obtain viable lymphocytes based on forward and side scatter and to discriminate between the CD45R/B220⁺ cell population (B-lymphocytes) and the CD45R/B220^neg cell population (T-lymphocytes) using an CD45R/B220-PE mAb and flow cytometric analysis. b One representative experiment showing the analysis of CFSE-stained B cells (after gating for viable cells); the percentage of proliferating cells (CFSE-lo) in control, diabetic and propolis-treated diabetic mice is indicated in each panel. c & d The data from the different experiments (n = 10) are expressed as the mean percentage of proliferating cells ± SEM in response to stimulation either with IL-4 and CD40L or with SEB in control mice (open bars), diabetic mice (black bars), or propolis-treated diabetic mice (hatched bars). ^* P < 0.05 for diabetic versus control; ^# P < 0.05 for diabetic + propolis versus diabetic; ⁺ P < 0.05 for diabetic + propolis versus control (ANOVA followed by Tukey’s post-test)