Table 1.
SNPs associated with both early onset MI and Salmonella-induced pyroptosis
| Early onset MI | Salmonella-induced pyroptosis | ||||||
|---|---|---|---|---|---|---|---|
| SNP | Chromosome | Gene | P value | Risk allele | P value | High pyroptosis allele | Concordant risk |
| rs6725887 | 2 | WDR12 | 1.00E-08 | C | 0.0088 | C | Yes |
| rs9305545, rs9982601 | 21 | - | 6.00E-11 | T | 0.0036 | G (T for rs9305545) | Yes |
| rs12526453, rs2327621 | 6 | PHACTR1 | 1.00E-09 | C | 0.005 | G (? for rs12526453) | ? |
| Summary | Observed | Expected | Enrichment | P value | P value (Bonferroni) | ||
| 3 | 0.08 | 37.5 | 5.9 × 10−5 | 0.003 | |||
P values for early onset MI association are from the NHGRI GWAS Catalog [1], while p values for pyroptosis were from [37]. Two SNPs are given in the same line where the lowest p value for early-onset MI and Salmonella-induced pyroptosis in the LD region are not the same SNP. The concordance of risk alleles for the two SNPs was determined by examining the direction of association for the early-onset MI SNP in the pyroptosis dataset. SNP rs12526453 shows no association with pyroptosis (despite rs2327621 showing an association), so the direction of effect is undetermined. P value for the significance of overlap was calculated with Fisher’s exact test